| Detailed Description: |
RecombinantHuman Leptin is a single non-glycosylated polypeptide chain containing 146amino acids and having a molecular weight of 16 kDa. The sequence of thefirst five N-terminal amino acids was determined to beAla-Val-Pro-Ile-Gln.；Leptin, the "satiety hormone", is a hormone made by fat cells which regulates the amount of fat stored in the body. It does this by adjusting both the sensation of hunger, and adjusting energy expenditures. Hunger is inhibited (satiety) when the amount of fat stored reaches a certain level. Leptin is then secreted and circulates through the body, eventually activating leptin receptors in the arcuate nucleus of the hypothalamus. Energy expenditure is increased both by the signal to the brain, and directly via leptin receptors on peripheral targets. The effect of leptin is opposite to that of ghrelin, the "hunger hormone". Ghrelin receptors are on the same brain cells as leptin receptors, so these cells receive competing satiety and hunger signals. Leptin and ghrelin, along with many other hormones, participate in the complex process of energy homeostasis.Leptin (Greek leptosmeaning thin) is a 16 kDa protein hormone that plays a key role in regulatingenergy intake and energy expenditure, including appetite and metabolism. Itis one of the most important adipose derived hormones. The Ob(Lep) gene (Obfor obes http://www.creative-diagnostics.com/Recombinant-Human-Leptin-a-a-146-Polypeptide-4253-427.htm
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