| Detailed Description: |
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimers and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]Major regulator ofsynaptic transmission and plasticity at adult synapses in many regions of theCNS. The versatility of BDNF is emphasized by its contribution to a range ofadaptive neuronal responses including long-term potentiation (LTP), long-termdepression (LTD), certain forms of short-term synaptic plasticity, as well ashomeostatic regulation of intrinsic neuronal excitability. http://www.creative-diagnostics.com/Recombinant-Human-Brain-Derived-Neurotrophic-Factor-Polypeptide-a-a-338-4259-427.htm
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